In St. Petersburg, a unique coating for vascular implants

Science

Illustration by Julia Chapurina

One of the main problems of patients with implanted structures (artificial blood vessels, stents) is a high probability of blood clots in them. As a result, patients are forced to take anticoagulants down to the end of their days, reducing blood coagulability.

To solve this problem unique development of scientists of the St. Petersburg ITMO University headed by Vladimir Vinogradov is called for. They created a vascular implant, the inner surface of which does not allow the formation of a thrombus.

The surface of the implant is a porous material, consisting of microspheres of aluminum oxide, which is not soluble in the blood. Inside is the key element – the urokinase activator of plasminogen. Placed in the pores of aluminum oxide, it remains immune to immunity, which in normal cases “attacks” it.

Being reliably protected from the influence of the external environment, the active ingredient does not prevent the penetration into the proenzyme of the plasminogen present in the blood. When a plasminogen matrix is ​​combined with an activator, a plasmin enzyme is formed that dissolves the nascent thrombus.

The unique system developed by St. Petersburg scientists helps to keep the drug inside the shell, so that the implant will serve for an unlimited time.

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